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KMID : 0613820040140010148
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Journal of Life Science
2004 Volume.14 No. 1 p.148 ~ p.153
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Effect of Terminalia chebula on Physiological Activity in Mice
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Park Jong-Ok
Lee Seung-Eun
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Abstract
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In this study, we investigated the effect of water extract of Terminalia Chebula (TC) on physiological activity in mice. TC water extract showed hemagglutination against several different types of red blood cells. LD50 of TC extract was 390 mg/kg (po). Treatment of TC water extract orally administered 200, 300 mg/kg daily for one week. Hepatic cytosolic enzymes, xanthine oxidase and aldehyde oxidase activities were significantly increased comparison with normal group. Treatment of TC water extract increased hepatic malondialdehyde (MDA) formation, and reduced glutathione content. We also found that the decreased activities of glutathione S-transferase and glutathione reductase but was not affected activities of γ-glutamylcysteine synthetase after treatment of TC water extract. These results suggested that increase of the hepatic lipid peroxide is caused by glutathione reduction.
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KEYWORD
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Terminalia Chebula, xanthine oxidase, aldehyde oxidase, glutathione, MDA
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